Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine
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چکیده
منابع مشابه
N-arachidonoyl L-serine, a putative endocannabinoid, alters the activation of N-type Ca2+ channels in sympathetic neurons.
The effect of N-arachidonoyl l-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca2+ channels of rat sympathetic ganglion neurons was determined using whole cell patch clamp. Application of ARA-S produced a rapid and reversible augmentation of Ca2+ current that was voltage dependent and resulted from a hyperpolarizing shift in the activation curve. ARA-S did not ...
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A set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel is a validated target for the treatment of refractory chronic pain. Despite being significantly less complex than the originally designed mimetics, up ...
متن کاملDifferential inhibition of T-type calcium channels by neuroleptics.
T-type calcium channels play critical roles in cellular excitability and have been implicated in the pathogenesis of a variety of neurological disorders including epilepsy. Although there have been reports that certain neuroleptics that primarily target D2 dopamine receptors and are used to treat psychoses may also interact with T-type Ca channels, there has been no systematic examination of th...
متن کاملN-Arachidonoyl L-Serine, a Putative Endocannabinoid, Alters the Activation of N-Type Ca Channels in Sympathetic Neurons
Guo J, Williams DJ, Ikeda SR. N-arachidonoyl L-serine, a putative endocannabinoid, alters the activation of N-type Ca channels in sympathetic neurons. J Neurophysiol 100: 1147–1151, 2008. First published January 30, 2008; doi:10.1152/jn.01204.2007. The effect of N-arachidonoyl L-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca channels of rat sympathetic gangl...
متن کاملThe biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine.
N-arachidonoyl dopamine (NADA) is an endogenous ligand that activates the cannabinoid type 1 receptor and the transient receptor potential vanilloid type 1 channel. Two potential biosynthetic pathways for NADA have been proposed, though no conclusive evidence exists for either. The first is the direct conjugation of arachidonic acid with dopamine and the other is via metabolism of a putative N-...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2009
ISSN: 0007-1188,1476-5381
DOI: 10.1111/j.1476-5381.2008.00072.x